About me 

I am a postdoctoral research fellow under the supervision of Dr. Peng Jiang at the National Cancer Institute (NCI), National Institutes of Health (NIH). I received my Ph.D. degree from School of Biological Sciences (SBS) at the University of Hong Kong (HKU), where I conducted research on cancer systems biology in Dr. Jiangwen Zhang's Lab. Prior to joining HKU, I earned my master's degree from School of Life Science and Technology (SLST), University of Electronic Science and Technology of China (UESTC), where I worked with Dr. Jian Huang on phage display informatics.

Education 

Period Degree Institute
2014 - 2018 Doctor of Philosophy (PhD) The University of Hong Kong (HKU)
2010 - 2013 Master of Science (MSc) University of Electronic Science and Technology of China (UESTC)
2006 - 2010 Bachelor of Science (BSc) University of Electronic Science and Technology of China (UESTC)

Research 

Period Projects
2019 - 2026
  • Develop a computational framework SpaCET for estimating cell lineages and intercellular interactions from tumor spatial transcriptomics (ST) data.
  • Design a platform SecAct inferring secreted protein activity and the cell-cell communication they mediate, while enabling users to query any human gene across 1,000+ tumor ST samples.
2014 - 2019
  • Build a comprehensive database CR2Cancer for chromatin regulators (CRs) in cancers through high-throughput data analysis and literature mining.
  • Design a framework CRAnalysis to identify aberrant CRs affected by genomic alterations as master regulators across eight cancer types from TCGA through integrating multi-dimensional omics data.
  • Develop an easy-to-use web server MR4Cancer that can prioritize master regulators (MRs) driving a cancer-related phenotypic divergence according to the input gene signatures.
  • Design an integrated portal TISIDB for tumor-immune system interactions, which includes multiple types of data resources in oncoimmunology including literature, high throughput data sets (i.e. cancer cohorts, screening and immunotherapy) and public databases.
2008 - 2014
  • Build a literature-based database MimoDB for mimotope data, which are peptide sequences derived from phage display technology.
  • Develop an online tool PhD7Faster that can identify clones propagating faster from the Ph.D.-7 phage display peptide library based on support vector machine.

Publications 

See a full list of publications here.

Links  

[ Google Scholar ] [ ResearchGate ] [ ORCID ] [ Loop ] [ GitHub ]